ARL15 Gene Variant rs255758 Provides Susceptibility to Rheumatoid Arthritis in Northwest Indian Population
Inder Mohan Singh Sandhu1, Hemender Singh2, Simranpreet Kaur1
1Department of Genetics, Sri Guru Ram Das Institute of Medical Sciences and Research, SGRDUHS, Amritsar, Punjab, India.
Introduction:
Rheumatoid arthritis (RA) is a systemic, chronic, and inflammatory autoimmune disease with a strong genetic component. ARL15 gene variant rs255758 has been reported as a candidate for RA susceptibility. A replication study was performed on this variant by taking 188 RA cases and 310 healthy non-RA controls from northwest India in a case-control association study design.
Materials And Methods:
DNA isolated from collected blood samples was analyzed by genotyping of the variant on real-time polymerase chain reaction using TaqMan Allele Discrimination Assay and statistically analyzed.
Results:
The variant was found to follow Hardy-Weinberg Equilibrium (P = 0.079) in the control group. The variant was significantly associated with RA susceptibility in the present studied population cohort (P = 0.024) with C as a risk allele and increased risk in the recessive model (CC vs. CA + AA; P = 0.004).
Conclusion:
The present study corroborates the earlier findings on the role of ARL15 gene variant rs255758 in RA and further contributes to its genetic etiology.
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