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Related Experiment Video

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Structural-Functional Correlation in Non-Arteritic Acute Ischemic Optic Neuropathy.

Junhan Wei1, Lei Zhang1, Haiyan Wang1

  • 1Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, People's Republic of China; Xi'an Key Laboratory of Digital Medical Technology of Ophthalmologic Imaging, Xi'an, 710004, People's Republic of China.

Eye and Brain
|May 8, 2025
PubMed
Summary

In non-arteritic ischemic optic neuropathy (NAION), ganglion cell-inner plexiform layer (GCIPL) thickness correlates with visual function. Thinner GCIPL and reduced visual field mean deviation predict worse visual acuity outcomes.

Keywords:
OCTOCTAischemic optic neuropathyvisual electrophysiologyvisual field

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Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • Non-arteritic ischemic optic neuropathy (NAION) is a leading cause of optic nerve damage.
  • Understanding the relationship between structural and functional changes in NAION is crucial for patient management.

Purpose of the Study:

  • To investigate the correlations between structural and functional parameters in patients with unilateral NAION.
  • To identify key indicators of optic nerve function and visual prognosis in acute NAION.

Main Methods:

  • Retrospective study of 29 NAION patients.
  • Comprehensive evaluations including visual acuity, optical coherence tomography (OCT), OCT angiography (OCTA), visual fields (VF), visual evoked potentials (VEP), electroretinography (ERG), and multifocal ERG (mf-ERG).
  • Follow-up assessments at three months post-presentation.

Main Results:

  • Acute NAION showed increased RNFL thickness and decreased GCIPL thickness.
  • Reduced VF mean deviation (MD) and VEP P100 amplitude, with prolonged latency, were observed.
  • Significant correlations found between GCIPL parameters and electrophysiological measurements (VEP, mf-ERG).
  • Baseline GCIPL thickness, VF MD, and VEP P100 amplitude correlated with visual acuity at 3-month follow-up.

Conclusions:

  • Retinal ganglion cell layer (GCIPL) thickness is a valuable objective indicator of optic nerve function in acute NAION.
  • Decreased VEP amplitude and mf-ERG response density correlate with GCIPL thickness.
  • Baseline visual field, VEP, and GCIPL thickness predict visual acuity at 3-month follow-up.