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Updated: May 12, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Synthesis and crystal structure of
Imane Faraj1, Lhoussaine El Ghayati1, Olivier Blacque2
1Laboratory of Heterocyclic Organic Chemistry Medicines Science Research Center Pharmacochemistry Competence Center Mohammed V University in Rabat Faculté des Sciences Av Ibn Battouta BP 1014 Rabat Morocco.
Abstract:
The title compound, C21H18N2O4, contains non-planar diazepine (in a boat-sofa conformation) and pyran (envelope) rings. In the crystal, O-H⋯O and N-H⋯O hydrogen bonds link the mol-ecules, enclosing R 2 2(16) and R 2 2(24) ring motifs, to generate [110] chains. Very weak π-π stacking inter-actions between the phenyl rings of adjacent mol-ecules with an inter-centroid distance of 4.0264 (9) Å help to consolidate a three-dimensional architecture. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H⋯H (45.1%), H⋯O/O⋯H (23.2%) and H⋯C/C⋯H (19.2%) inter-actions.
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