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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Related Experiment Video

Updated: May 12, 2025

A Mouse Model of Intestinal Partial Obstruction
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Aggressive Extramedullary Multiple Myeloma Presenting as Small Bowel Obstruction.

Paul J Wurtz1, Kevin McGovern2, Jamie Shah3

  • 1Department of Internal Medicine, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA.

Journal of Hematology
|May 8, 2025
PubMed
Summary

Extramedullary multiple myeloma (EMM) is a rare cancer subtype. This aggressive case presented as a small bowel obstruction, highlighting the need for dedicated EMM clinical trials.

Keywords:
Extramedullary multiple myelomaHepatic plasmacytomaIron deficiency anemiaPlasmacytomaSmall bowel obstruction

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Area of Science:

  • Hematology
  • Oncology
  • Gastroenterology

Background:

  • Extramedullary multiple myeloma (EMM) is a rare subset of multiple myeloma (MM).
  • EMM is characterized by clonal plasma cells (PCs) outside the bone marrow.
  • It is associated with refractory disease and poor outcomes.

Observation:

  • Intestinal plasmacytomas in EMM are rare, with fewer than 70 cases reported.
  • This case involved an aggressive EMM with an intraluminal plasmacytoma causing small bowel obstruction.
  • The obstruction occurred during myeloma-directed therapy.

Findings:

  • The patient underwent surgical resection and anastomosis.
  • Treatment was followed by cytotoxic chemotherapy and autologous stem cell rescue.
  • This aggressive EMM case presented unique management challenges.

Implications:

  • Management of aggressive EMM differs from standard MM.
  • Dedicated clinical trials for aggressive EMM are needed.
  • Further research can elucidate EMM's unique pathophysiology and improve survival.