Predictive Factors for Procedure Time for Closure of Mucosal Defect Following Colorectal Endoscopic Submucosal...

Area of Science:

• Gastroenterology
• Endoscopic Surgery
• Colorectal Surgery

Background:

• Closure of mucosal defects after colorectal endoscopic submucosal dissection (ESD) is crucial for preventing complications.
• Colorectal ESD defect closure presents challenges, potentially increasing procedure time.
• Limited data exist on predictive factors for colorectal ESD closure duration.

Purpose of the Study:

• To identify predictive factors influencing the procedure time for closing mucosal defects after colorectal ESD.
• To establish a model for predicting closure time to optimize treatment planning.

Main Methods:

• A cohort of 61 patients undergoing colorectal ESD for large neoplasms (>20 mm) was analyzed.
• Mucosal defects were closed using a loop clip closure method immediately post-ESD.
• Multiple linear regression analyses were employed to evaluate factors affecting closure procedure time.

Main Results:

• Resected specimen size (β=0.690, p<0.01) and colon site (β=-0.209, p=0.027) were significant predictors of closure time.
• These factors explained 50.5% of the variance in closure procedure time, indicating a good model fit.

Conclusions:

• Predictive factors for colorectal ESD closure time have been clarified.
• The established model demonstrates good predictive accuracy, facilitating informed closure performance and treatment planning.