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Related Concept Videos

Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Fatigue01:21

Fatigue

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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Myasthenia Gravis: Diagnostic Tests01:15

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Fatigue Strength of Concrete01:22

Fatigue Strength of Concrete

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Fatigue, in the context of materials science and engineering, refers to the weakening or failure of a material caused by repeatedly applied loads, even if these loads are below the strength limit of the material. Fatigue strength in concrete is a critical property that influences its durability and longevity. Concrete can fail in two ways due to fatigue. Static fatigue or creep rupture occurs under a constant load or one that increases slowly. The other failure mode is due to cyclical or...
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Noninferiority Randomized Clinical Trial Comparing Three Delivery Formats of a Rehabilitation Intervention to Reduce Fatigue Among Individuals With Multiple Sclerosis.

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Appreciating the experience of multiple sclerosis fatigue.

Toni Van Denend1, Maureen Gecht-Silver2, Jacqueline Kish3

  • 1Department of Occupational Therapy, University of Illinois Chicago, Chicago, IL, USA.

The British Journal of Occupational Therapy
|May 8, 2025
PubMed
Summary

People with multiple sclerosis (MS) describe their fatigue in various ways, impacting their daily participation. Understanding these experiences is key for effective management and support.

Keywords:
Fatiguemultiple sclerosisparticipationqualitative researchself-management

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Area of Science:

  • Neurology
  • Occupational Therapy
  • Qualitative Research

Background:

  • Fatigue is a prevalent and debilitating symptom in multiple sclerosis (MS).
  • MS fatigue significantly hinders participation in daily roles and activities.
  • Effective management of MS fatigue is crucial for improving quality of life.

Purpose of the Study:

  • To explore how individuals with MS describe and explain their fatigue experiences.
  • To gain deeper insights into the lived experience of MS fatigue.
  • To inform fatigue management strategies within clinical practice.

Main Methods:

  • Secondary qualitative analysis of interventionists' treatment notes from a fatigue management randomized clinical trial.
  • Analysis of subjective and objective clinical documentation from 85 participants.
  • Utilized a qualitative research design with multiphase coding.

Main Results:

  • Identified four major themes: Fatigue Nature, Struggle, Responding to the Reality of Fatigue, and Impact on Participation.
  • Discovered 11 subthemes providing nuanced details within the major themes.
  • Highlighted the diverse ways individuals with MS articulate their fatigue.

Conclusions:

  • The subjective descriptions of MS fatigue are varied and complex.
  • Findings can enhance occupational therapists' empathy and understanding of MS fatigue.
  • Improved understanding facilitates better collaboration and support for individuals with MS fatigue.