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Updated: May 12, 2025

Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology
Published on: July 5, 2022
Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression
Sarah Henretta1,2, Jan Lammerding1,2
1Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY USA.
Abstract:
Breast cancer cells frequently exhibit changes in the expression of nuclear envelope (NE) proteins such as lamins and emerin that determine the physical properties of the nucleus and contribute to cellular mechanotransduction. This review explores the emerging interplay between NE proteins, the physical challenges incurred during metastatic progression, and mechanotransduction. Improved insights into the underlying mechanisms may ultimately lead to better prognostic tools and treatment strategies for metastatic breast cancer.
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