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The relationship between oral burns and oral squamous cell carcinoma: a systematic review

Shiva Kiasati1, Mitra Rostami2, Zaid Mustafa Akram3

  • 1School of Dentistry, International Campus, Tehran University of Medical Sciences, Tehran, Iran.

Annals of Medicine and Surgery (2012)
|May 8, 2025
PubMed
Abstract

Insights

Micro-RNAs (miRNAs) are key in oral burns and oral squamous cell carcinoma (OSCC). This review found 5 shared miRNAs, highlighting their potential role in linking oral burns to OSCC development.

Area of Science:

  • Molecular biology
  • Oncology
  • Oral medicine

Background:

  • Micro-RNAs (miRNAs) regulate biological processes and are implicated in diseases like cancer.
  • Emerging research suggests a potential role for miRNAs in the connection between oral burns and oral conditions.
  • Oral squamous cell carcinoma (OSCC) is a significant oral malignancy.

Purpose of the Study:

  • To systematically review and summarize the current evidence on the roles of miRNAs in the relationship between oral burns and OSCC.
  • To identify specific miRNAs involved in both oral burns and oral carcinogenesis.

Main Methods:

  • A systematic literature search was conducted across multiple databases (PubMed, Google Scholar, etc.) from April to May 2024.
  • Keywords included "oral burn", "burning tongue", "burning mouth", "Oral squamous cell carcinoma", and "miRNA".
  • The review followed the "Preferred Reporting Items for Systematic Reviews" (PRISMA) guidelines.

Main Results:

  • Nine publications were reviewed, focusing on miRNA interactions in oral burns and cancers.
  • Five shared miRNAs were identified between oral burns and oral cancers.
  • hsa-miR-205, hsa-miR-18a, hsa-mir-23b, hsa-mir-203, and hsa-mir-150 were noted for their distinct roles in burns and carcinogenesis.

Conclusions:

  • The findings underscore the potential significance of miRNAs in the interplay between oral burns and OSCC.
  • Further research is warranted to elucidate the precise mechanisms.
  • miRNAs represent a promising area for understanding and potentially targeting OSCC development following oral burns.
Keywords:
burnsmicro-RNAoral burnsoral squamous cell carcinomasystematic review

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