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Exposure to specific Volatile Organic Compounds (VOCs) is linked to increased Cardiometabolic Index (CMI), indicating higher cardiovascular and metabolic risk. Body Mass Index (BMI) and diabetes status significantly influence this relationship, highlighting environmental impacts on health.

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Area of Science:

  • Environmental Health
  • Cardiovascular Health
  • Metabolic Health

Background:

  • Volatile Organic Compounds (VOCs) are environmental pollutants linked to cardiovascular diseases and metabolic disorders.
  • The Cardiometabolic Index (CMI) is a key metric for assessing cardiovascular and metabolic health.
  • Understanding the impact of VOC exposure on CMI is crucial for public health.

Purpose of the Study:

  • To investigate the association between exposure to specific VOCs and the Cardiometabolic Index (CMI).
  • To explore the impact of VOC mixtures on CMI.
  • To examine how BMI and diabetes status modify the relationship between VOC exposure and CMI.

Main Methods:

  • Utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2011-2020.
  • Employed multivariable linear regression, restricted cubic spline models, Bayesian Kernel Machine Regression (BKMR), Weighted Quantile Sum (WQS), and Quantile G-computation (Q-gcomp) to analyze VOC-CMI associations.
  • Conducted subgroup analyses to assess the influence of BMI and diabetes status.

Main Results:

  • Significant positive associations were found between CEMA, 3HPMA, MHBMA3, and HMPMA exposure and CMI.
  • Nonlinear relationships were observed between AAMC and SBMA exposure and CMI.
  • Mixture models identified CEMA as a major contributor to CMI changes, with overall VOC exposure showing a positive trend with CMI.
  • Subgroup analyses revealed significant interactions with BMI (≥30) and diabetes status.

Conclusions:

  • Specific VOC exposures are significantly associated with elevated CMI.
  • BMI and diabetes status are critical moderators in the VOC-CMI relationship.
  • Findings underscore the public health implications of environmental VOCs on cardiometabolic health.