Non-linear relationship between Dietary Inflammatory Index and constipation: threshold identification and insights...

Area of Science:

• Gastroenterology
• Nutritional Science
• Public Health

Background:

• Constipation is a growing global health issue.
• Traditional treatments have limitations.
• Dietary adjustments offer a convenient therapeutic approach.

Purpose of the Study:

• To explore the association between the Dietary Inflammatory Index (DII) and constipation.
• To identify potential dietary strategies for constipation prevention and management.

Main Methods:

• Utilized National Health and Nutrition Examination Survey (NHANES) data (2005-2010).
• Assessed constipation using bowel movement frequency and stool characteristics.
• Calculated DII from 24-hour dietary recall data.
• Employed regression models, inverse probability of treatment weighting (IPTW), restricted cubic splines (RCS), and Mendelian randomization.

Main Results:

• Higher DII scores correlated with increased constipation risk (OR 2.85 in Q4 vs. Q1).
• A nonlinear relationship was observed, with a threshold DII of 0.974.
• Gender, income, and diabetes status modified the DII-constipation association.

Conclusions:

• A nonlinear relationship exists between DII and constipation risk with a specific threshold.
• Dietary inflammatory potential influences constipation risk differently across demographic and health groups.
• The DII can inform constipation prevention and intervention strategies.