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Interleukin-24: A Multidimensional Therapeutic for Treatment of Human Diseases

Rajeswari Raguraman1, Anupama Munshi2, Rajagopal Ramesh1

  • 1Department of Pathology, and OU Health Stephenson Cancer Center, University of Oklahoma Health Sciences, Oklahoma City, Oklahoma, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|May 8, 2025
PubMed

Insights

Interleukin-24 (IL-24) shows promise as an anti-cancer targeted therapy, with successful outcomes in combination treatments. Further research is needed to explore IL-24

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Targeted therapy offers a promising approach for treating diseases by selectively targeting diseased cells.
  • Interleukin-24 (IL-24), a cytokine, has demonstrated significant potential as an anti-cancer therapeutic agent.
  • While extensively studied in cancer, the role of IL-24 in other human diseases remains largely unexplored.

Purpose of the Study:

  • To review the current progress of IL-24 in cancer therapy.
  • To explore the potential role of IL-24 in diverse human diseases beyond cancer.
  • To discuss limitations and future directions for IL-24-based targeted therapy.

Main Methods:

  • Comprehensive literature review of preclinical and clinical studies on IL-24 in cancer.
  • Analysis of existing data on IL-24's therapeutic potential in various disease models.
  • Discussion of translational challenges and proposed solutions for IL-24-based therapies.

Main Results:

  • IL-24 exhibits potent tumor-suppressing properties and has shown efficacy in combination therapies.
  • Successful outcomes have been reported with IL-24 in combination with small molecule inhibitors, chemotherapy, and radiation.
  • Evidence suggests IL-24's potential applicability in a broader range of human diseases.

Conclusions:

  • IL-24 represents a viable and promising targeted therapeutic agent, particularly in oncology.
  • Expanding research into IL-24's role in non-cancerous diseases could uncover new therapeutic avenues.
  • Addressing translational limitations is crucial for realizing the full clinical potential of IL-24-based therapies.
Keywords:
cancerinterleukin‐24nanomedicinetargeted therapy

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