Noncoding RNAs and their influence on maternal mental health: insights into perinatal depression: a review

Perinatal depression profoundly influences the psychological and physiological well-being of women both during and after pregnancy. This condition encompasses depressive symptoms that manifest as antenatal as well as postnatal depression. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), are integral to various cellular processes and have been implicated in the pathophysiology of perinatal depression. These ncRNAs are involved in the regulation of gene expression, maintenance of neuronal function, and modulation of stress responses. Dysregulation of ncRNAs, particularly lncRNAs and miRNAs, has been associated with psychiatric disorders, including perinatal depression. This review explores the classification and functions of ncRNAs, their biological roles, and the evidence linking them to perinatal depression. The investigation of ncRNAs in the context of perinatal depression holds promise for the development of novel therapeutic strategies and the enhancement of health outcomes for both mothers and their children. Future research should prioritize the standardization of methodologies and approaches in this field.