Preoperative total bile acid can be used as a prognostic biomarker in patients with operable biliary tract cancers
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View abstract on PubMed
Summary
This summary is machine-generated.Total bile acid (TBA) levels may predict survival in biliary tract cancer (BTC) patients. Increased TBA indicates longer survival, while tumor location and elevated cancer antigen (CA)125 and CA19-9 levels suggest shorter survival.
Area Of Science
- Oncology
- Hepatology
- Biochemistry
Background
- Biliary tract cancers (BTCs) are aggressive malignancies with limited prognostic biomarkers.
- Altered lipid metabolism is increasingly recognized in digestive cancers, with the liver central to these processes.
Purpose Of The Study
- To investigate the association between hepatic lipid metabolism indicators, measurable via routine blood tests, and survival outcomes in BTC patients.
Main Methods
- Retrospective analysis of 109 BTC patients diagnosed between 2017 and 2023.
- Utilized univariate and multivariate Cox regression analyses and Kaplan-Meier survival curves.
Main Results
- Elevated preoperative total bile acid (TBA) levels were independently associated with longer survival (HR=0.445, P=0.004).
- Tumor location (intrahepatic/extrahepatic cholangiocarcinoma) and increased cancer antigen (CA)125 and CA19-9 levels were independent predictors of shorter survival (HRs ranging from 2.100 to 2.549, P<0.05).
- Kaplan-Meier analysis confirmed longer survival with higher TBA levels and shorter survival with advanced tumor location and elevated CA125/CA19-9.
Conclusions
- Total bile acid (TBA) shows potential as a predictive biomarker for survival in operable BTC.
- These findings underscore the clinical significance and applicability of TBA in BTC prognosis.
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