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A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
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CancerPPD2: an updated repository of anticancer peptides and proteins

Milind Chauhan1, Amisha Gupta1, Ritu Tomer1

  • 1Department of Computational Biology, Indraprastha Institute of Information Technology, Okhla Phase 3, New Delhi 110020, India.

Database : the Journal of Biological Databases and Curation
|May 8, 2025
PubMed

Insights

CancerPPD2 is an enhanced database of anticancer peptides and proteins, offering comprehensive data on 6521 entries. This updated resource aids cancer research by providing detailed information and advanced search tools for anticancer agents.

Area of Science:

  • Biochemistry
  • Bioinformatics
  • Oncology

Background:

  • Anticancer peptides and proteins are crucial in cancer therapy.
  • Existing databases may lack comprehensive and updated information on these agents.
  • The need for a centralized, detailed repository for anticancer peptide and protein data is evident.

Purpose of the Study:

  • To present CancerPPD2, an updated and expanded version of the CancerPPD database.
  • To provide a comprehensive resource for anticancer peptides and proteins, including their origin, sequence, structure, and activity.
  • To facilitate cancer research through integrated data retrieval and analysis tools.

Main Methods:

  • Compilation of 6521 entries on anticancer peptides and proteins.
  • Inclusion of data on natural, chemically modified, and terminus-modified peptides.
  • Integration of structural data from Protein Data Bank (PDB) and prediction tools (PEPstrMOD, I-TASSER, AlphaFold).
  • Linking entries to clinical studies and other databases (Uniprot, DrugBank, ThPDB2).
  • Development of a REST API for programmatic data access.

Main Results:

  • CancerPPD2 contains 6521 entries, significantly expanding upon its predecessor.
  • Data covers peptides tested against 392 cancer cell lines and 28 cancer-associated tissues.
  • Includes 781 chemically modified and 3018 N-/C-terminus modified anticancer peptide entries.
  • Cross-references to 47 clinical studies and clinical trials are provided.
  • Enhanced data retrieval and similarity search tools, plus a REST API, are integrated.

Conclusions:

  • CancerPPD2 serves as a valuable, comprehensive resource for anticancer peptides and proteins.
  • The database supports researchers in identifying and analyzing potential anticancer agents.
  • Integrated tools and API facilitate advanced data mining and application in cancer drug discovery.

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