One-Pot Three-Component Coupling of Arylhydrazines with Aryl Aldehydes to Access the Triarylmethane Scaffold
Dong Wang1, Mingxia Liu1, Shuo Zhang1
1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, China.
Abstract:
We herein report a one-pot, three-component coupling of arylhydrazine HCl salts with aryl aldehydes to synthesize a triarylmethane scaffold. This reaction proceeds under simple, mild, and practical conditions without the need for an additional Bro̷nsted or Lewis acid additive, accommodating a broad substrate scope with good to excellent yields. Furthermore, this methodology can be scaled up and allows access to a diverse range of triarylmethane derivatives. Mechanistic studies suggest that the in situ formed hydrazone intermediate is essential for the high efficiency and selectivity of this transformation.
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