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Updated: May 17, 2025

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Comparable gut mucosal breakdown and microbial translocation in severe COVID-19 with and without HIV infection

Sabrina Marozin1, Valeria Bono1, Martina Mazzoccoli1

  • 1Clinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan.

AIDS (London, England)
|May 8, 2025
PubMed

Insights

This study investigated gut damage in people with HIV (PWH) hospitalized with severe COVID-19. Findings indicate SARS-CoV-2 pneumonia may cause gut damage regardless of HIV status, suggesting further research into COVID-19 severity.

Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Immunology

Background:

  • Severe COVID-19 presents unique challenges in people with HIV (PWH).
  • Gut barrier dysfunction is a potential complication of severe infections.
  • Understanding gut health in PWH with COVID-19 is crucial.

Purpose of the Study:

  • To explore the association between gut impairment and severe COVID-19 outcomes in PWH.
  • To compare gut barrier dysfunction markers in PWH with COVID-19 versus HIV-uninfected individuals with COVID-19.

Main Methods:

  • Comparative analysis of gut barrier dysfunction markers.
  • Inclusion of PWH and HIV-uninfected individuals hospitalized with COVID-19.
  • Assessment of clinical symptom severity.

Main Results:

  • PWH experienced more severe clinical symptoms of COVID-19.
  • No significant differences in gut barrier dysfunction markers were observed between PWH and HIV-uninfected groups.
  • SARS-CoV-2 pneumonia was linked to gut damage irrespective of HIV status.

Conclusions:

  • Gut damage in severe COVID-19 may be independent of HIV status.
  • Further research is needed to elucidate the role of gut damage in COVID-19 severity.
  • Findings highlight the complex interplay between viral infection, gut health, and host factors.

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