Related Experiment Video
Updated: May 15, 2025
Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells
Published on: November 18, 2022
Diarylheptanoid-flavanone adducts from Alpinia officinarum and their neuroprotective activities
Teng Ren1, Qiuping Miao1, Yan Pan1
1State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China; Center for Bioactive Natural Molecules and Innovative Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
Abstract:
Guided by the characteristic highly π-conjugated system of HPLC-UV experiments, four pairs of enantiomeric diarylheptanoid-flavanone adducts, officinoids A-D (1-4), were isolated from the rhizomes of medicinal plant Alpinia officinarum. Their structures with absolute configurations were fully characterized through a combination of extensive spectroscopic analysis, single-crystal X-ray diffraction, and density functional theory quantum chemical calculation. These isolated compounds represent a new class of diarylheptanoid-flavanone adducts with an unprecedented C-11-C-8'(C-6') and C-9-O-C-7' connection mode. Notably, compounds 3 and 4 contain an unusual ketal motif in the dihydropyrano[2,3-f]chromone or dihydropyrano[3,2-g]chromone skeleton. In the bioactivity assays, compound 2 exhibited significant neuroprotective effects against neuronal injury induced by oxygen-glucose deprivation and re‑oxygenation (OGD/R) in SH-SY5Y cells.
More Related Videos
06:17A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
Published on: May 22, 2018
10:25Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
Published on: November 22, 2024
Related Concept Videos
01:16Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
01:29Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
01:23Protecting Groups for Aldehydes and Ketones: Introduction
01:30Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
01:18Indirect-Acting Cholinergic Agonists: Mechanism of Action
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex,...
01:24Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...