Endocrine disrupting chemicals alter neuronal circuits controlling reproduction and appetite
Anneline Pinson1, Chloé Glachet1, Charlotte Jacquinet1
1Neuroendocrinology Unit, GIGA Neurosciences, University of Liège, Liège, Belgium.
Abstract:
Exposure to endocrine disrupting chemicals during critical periods of development can result in detrimental long-term health consequences. The hypothalamus is extremely sensitive to endocrine disrupting chemicals, which could participate to the increase in metabolic and reproduction related diseases. We propose the concept according to which exposure to low levels of endocrine disrupting chemicals induces developmental and transgenerational alterations of sexual maturation and energy balance through reprograming of the hypothalamus.
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