Related Experiment Video
Updated: Jun 14, 2025

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
Published on: March 29, 2018
Relations between developmental dental defects and exposure to environmental toxicants exhibiting endocrine
Sylvie Babajko1, Catherine Chaussain2, Katia Jedeon2
1Université Paris Cité, université Sorbonne Paris Nord, Inserm UMR1333 Oral Heath, Montrouge, France.
Abstract:
Increased prevalence of developmental defects of enamel reported in recent studies suggests the involvement of novel environmental causal factors. Among them, toxicants with endocrine disrupting activity retain our attention for their ability to disrupt tooth development, notably the synthesis of the two main dental tissues, enamel and dentin, submitted to hormonal control. As dental tissue mineralization follows a well-known sequence of events that starts during fetal life and mostly ends 6 years after birth, with enamel being assimilated to a fossil, dental defects can be considered as good markers of exposure to environmental pollutants especially those with endocrine disrupting activity. The cellular effects and mechanisms of action of some of them, including pro-estrogenic and anti-androgenic compounds, are presented here.
More Related Videos
07:08Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
08:28Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
Published on: April 26, 2018
Related Concept Videos
Teratogenicity
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Gene-Environment Interactions
Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
Mutagenicity and Carcinogenicity
Environmental Influences on Intelligence