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The correlation between serum 25-hydroxyvitamin D3 and oxidative balance score in patients with tuberculosis infection

  • 0Zhejiang Tuberculosis Diagnosis and Treatment Center, Zhejiang Chinese and Western Medicine Integrated Hospital, Hangzhou, Zhejiang, China.
Enfermedades Infecciosas Y Microbiologia Clinica (english Ed.) +

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May 8, 2025

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May 8, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Serum 25-hydroxyvitamin D3 (25(OH)D3) is linked to oxidative balance in tuberculosis patients. Vitamin D levels below 51.9nmol/L show a significant association, suggesting its potential role in TB treatment.

Area Of Science

  • Biochemistry
  • Nutritional Science
  • Infectious Diseases

Background

  • Tuberculosis (TB) is associated with an imbalance of pro- and anti-oxidants, influencing disease progression.
  • Identifying key oxidative stress indicators is crucial for understanding TB pathogenesis.

Purpose Of The Study

  • To identify the primary oxidative stress indicator related to oxidative balance in TB patients.
  • To investigate the relationship between serum 25-hydroxyvitamin D3 (25(OH)D3) and the oxidative balance score (OBS) in TB.

Main Methods

  • Utilized trend regression, generalized additive models, polynomial regression, and threshold effect analysis on 339 TB participants.
  • Examined the correlation between serum 25(OH)D3 and OBS components using Pearson and mediation analyses.

Main Results

  • Serum 25(OH)D3 was the only indicator independently associated with OBS in TB patients.
  • A non-linear positive association was observed, with a threshold effect at 51.9nmol/L for 25(OH)D3.
  • Body Mass Index (BMI) and riboflavin mediated the relationship between 25(OH)D3 and OBS.

Conclusions

  • Serum 25(OH)D3 is significantly related to oxidative balance in TB patients.
  • Vitamin D status, particularly levels below 51.9nmol/L, may play a role in TB management.
  • This study provides evidence supporting vitamin D's potential as an adjunct therapy for TB.

Keywords:

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