Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

5.5K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.5K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.1K
Genomics02:02

Genomics

35.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wearable measured physiological stress and activity patterns changes after 2025 Los Angeles wildfire among older adults: findings from a pilot prospective cohort study.

Environmental research, health : ERH·2026
Same author

Automated Text Message Outreach to Increase Diabetes Screening: A Pragmatic Randomized Trial.

medRxiv : the preprint server for health sciences·2026
Same author

Yield of Family Screening in Arrhythmogenic Right Ventricular Cardiomyopathy Without a Validated Genetic Cause.

Circulation. Arrhythmia and electrophysiology·2026
Same author

Identifying and mitigating bias in multiple aspects of modern clinical research.

Communications medicine·2026
Same author

Unaddressed implications of the FDA's 2026 guidance on wellness devices.

Nature biomedical engineering·2026
Same author

Simplified Tools, Complex Decisions: These Are Rhythm Procedures: Why AF Ablation, Leadless Pacing, and Left Atrial Appendage Occlusion Require Rhythm-Centered Care.

Circulation. Arrhythmia and electrophysiology·2026

Related Experiment Video

Updated: May 12, 2025

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

1.6K

Data Interoperability and Harmonization in Cardiovascular Genomic and Precision Medicine.

C Anwar A Chahal1,2,3, Fares Alahdab4, Babken Asatryan5

  • 1Department of Heart and Vascular, Center for Inherited Cardiovascular Diseases, WellSpan Health, York, PA (C.A.A.C.).

Circulation. Genomic and Precision Medicine
|May 9, 2025
PubMed
Summary

Fragmented healthcare systems hinder precision medicine. Integrating big data and harmonizing health records can accelerate cardiovascular genomic and precision medicine advancements.

Keywords:
big dataelectronic health recordsnatural language processingphenomicstranslational research, biomedical

More Related Videos

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

10.9K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.0K

Related Experiment Videos

Last Updated: May 12, 2025

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

1.6K
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

10.9K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.0K

Area of Science:

  • Cardiovascular Medicine
  • Genomics
  • Precision Medicine
  • Health Informatics

Background:

  • Despite advances, healthcare fragmentation and data access issues impede precision medicine implementation.
  • Precision medicine requires robust omics and phenomics data, ideally from electronic health records.
  • Big data strategies have improved non-cardiovascular therapeutics; similar approaches can advance cardiovascular precision medicine.

Purpose of the Study:

  • To review best practices in cardiovascular genomic and precision medicine.
  • To provide recommendations for system requirements to accelerate platform integration.

Main Methods:

  • State-of-the-art literature review.
  • Analysis of current endeavors in data harmonization (e.g., AHA Precision Medicine platform, BigData@Heart, NIH All of Us Terra platform).

Main Results:

  • Identified challenges in data collection, access, and system integration.
  • Highlighted ongoing efforts in data harmonization across major initiatives.
  • Summarized best practices for genomic and precision medicine applications.

Conclusions:

  • Addressing healthcare system fragmentation and data disparities is crucial for advancing cardiovascular precision medicine.
  • Harmonizing data temporally and ontologically is key to leveraging big data effectively.
  • Recommendations for system requirements can accelerate the integration and impact of precision medicine platforms.