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Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

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Acellular Scaffolds for Muscle Regeneration: Advances and Challenges.

Jessica Mroueh¹, Luisa Weber^1,2, Yori Endo¹

¹Division of Plastic and Reconstructive Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Advances in Wound Care

|May 9, 2025

Summary

Tissue engineering scaffolds show promise for treating volumetric muscle loss, a severe condition causing functional impairment. Optimizing scaffold properties is key to enhancing muscle regeneration and overcoming current limitations in treatment.

Keywords:

acellular scaffold decellularization natural polymers skeletal muscle regeneration synthetic polymers volumetric muscle loss

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Published on: August 24, 2017

Area of Science:

Biomedical Engineering
Regenerative Medicine
Tissue Engineering

Background:

Volumetric muscle loss (VML) involves significant muscle mass reduction, leading to permanent functional deficits.
Current treatment options for VML are limited, highlighting the need for innovative therapeutic approaches.
Tissue engineering using biocompatible scaffolds presents a promising strategy for VML treatment and muscle regeneration.

Purpose of the Study:

To explore the potential of tissue engineering scaffolds in addressing volumetric muscle loss.
To review recent advances in scaffold-based therapies for severe muscle injuries.
To identify critical issues and future directions for optimizing scaffold-mediated muscle regeneration.

Main Methods:

Review of emerging strategies involving bioactive molecules and growth factors within biocompatible scaffolds.
Analysis of scaffold functions as drug-delivery devices, cellular matrices, and growth factor reservoirs.
Examination of scaffold properties such as fiber diameter, alignment, cellular cues, and porosity.

Main Results:

Scaffolds can deliver bioactive molecules and growth factors to promote muscle healing.
Optimizing scaffold characteristics is crucial for successful engraftment and regeneration.
Current limitations include scaffold engraftment and efficacy in promoting tissue regeneration.

Conclusions:

Biocompatible scaffolds offer a promising therapeutic avenue for volumetric muscle loss.
Further research into scaffold optimization and host tissue interactions is essential for improving functional muscle reconstitution.
Advancing mechanistic understanding will guide the development of more effective regenerative strategies.