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Published on: January 28, 2019
Comparative analysis of immunogenicity between first-dose measles-mumps-rubella (MMR) vaccine administration and
Xue-Feng Liang1, Xiao-Shu Zhang1, Jing An1
1Immunization Planning and Management Institute, Gansu Provincial Center for Disease Control and Prevention, Lanzhou, China.
Abstract:
This study compared the immunogenicity of the measles-mumps-rubella (MMR) vaccine when administered alone versus when co-administered with the rotavirus vaccine in infants aged 8-9 months. In this prospective cohort study, 1,198 infants were enrolled: 800 received combined MMR and rotavirus vaccines (experimental group), while 398 received the MMR vaccine alone (control group). A Hurdle Gamma model analyzed vaccination impact on antibody levels in both groups and the correlation between antibody responses. Geometric mean concentrations of measles, rubella, and mumps IgG antibodies increased significantly in both groups after vaccination. The experimental group demonstrated 209-fold, 25-fold, and 12-fold increases, respectively, with comparable increases in the control group. Hurdle Gamma model analysis revealed significant positive effects of vaccination on all three antibody levels, with no significant differences between MMR-rotavirus combined vaccination and MMR vaccination alone. Random effects analysis showed strong negative correlations for measles and rubella IgG antibodies (correlation coefficients: -1.00 and -0.99, respectively) and a moderate negative correlation for mumps IgG antibodies (correlation coefficient: -0.56). This study represents the first application of a Hurdle Gamma model to compare immunogenicity between standalone MMR vaccination and combined MMR-rotavirus vaccination. The results demonstrate equivalent MMR antibody responses between these two vaccination approaches.
Insights
The measles-mumps-rubella (MMR) vaccine shows similar immunogenicity whether given alone or with the rotavirus vaccine in infants. This finding supports combined vaccination schedules for efficient infant immunization.
Area of Science:
- Pediatric Vaccinology
- Immunology
- Public Health
Background:
- Infant vaccination schedules often involve multiple vaccines.
- Assessing the immunogenicity of combined vaccines is crucial for efficacy.
- The measles-mumps-rubella (MMR) vaccine is a standard immunization for infants.
Purpose of the Study:
- To compare the immunogenicity of the MMR vaccine when administered alone versus combined with the rotavirus vaccine in infants.
- To evaluate antibody responses to measles, mumps, and rubella following vaccination.
- To investigate potential correlations between antibody responses in infants receiving combined vaccines.
Main Methods:
- Prospective cohort study involving 1,198 infants aged 8-9 months.
- Comparison of two groups: MMR vaccine alone (control) and combined MMR-rotavirus vaccine (experimental).
- Hurdle Gamma model and random effects analysis to assess antibody levels and correlations.
Main Results:
- Significant increases in measles, rubella, and mumps IgG antibodies observed in both vaccination groups.
- No significant differences in MMR vaccine immunogenicity between standalone and combined administration.
- Strong negative correlations found between measles and rubella antibody levels, and moderate for mumps.
Conclusions:
- Combined MMR-rotavirus vaccination elicits comparable MMR-specific antibody responses to standalone MMR vaccination in infants.
- The Hurdle Gamma model provides a novel approach for analyzing vaccine immunogenicity data.
- Findings support the feasibility of co-administering MMR and rotavirus vaccines without compromising MMR immunogenicity.
