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Pentraxin-3 and C-reactive protein plasma levels predict survival in older adults with or without metabolic syndrome - results of the PolSenior2 substudy

  • 0Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Katowice, Poland. aowczarek@sum.edu.pl.
Immunity & Ageing : I & A +

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May 9, 2025

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May 9, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Elevated levels of pentraxin-3 (PTX-3) and C-reactive protein (CRP) in older adults indicate a higher risk of mortality, irrespective of metabolic syndrome (MS). This inflammation marker association with death risk is significant even with single elevated markers.

Area Of Science

  • Biomedical research
  • Gerontology
  • Inflammation markers

Background

  • Vascular inflammation and mortality risks in older adults with metabolic syndrome (MS) are not well-documented.
  • Pentraxin-3 (PTX-3) is a marker of vascular inflammation.
  • C-reactive protein (CRP) is a common inflammation marker.

Purpose Of The Study

  • To compare the prognostic significance of elevated PTX-3 and CRP levels on overall survival in older adults (≥60 years).
  • To investigate these associations in individuals with and without metabolic syndrome (MS).

Main Methods

  • 3534 participants were categorized by MS status and stratified by CRP and PTX-3 plasma concentrations.
  • Subgroups included double-negative (low CRP/PTX-3), single-positive (elevated CRP or PTX-3), and double-positive (elevated CRP and PTX-3).
  • Follow-up was 4.19 years, with 678 deaths recorded.

Main Results

  • Increased death rates were observed in single-positive and were highest in double-positive subgroups, with or without MS.
  • The risk of death was 34-44% higher in single-positive and over 2-3 times higher in double-positive subgroups.
  • Metabolic syndrome did not affect survival within these inflammatory marker categories.

Conclusions

  • Elevated plasma levels of both PTX-3 and CRP are associated with a higher risk of all-cause mortality in older Caucasians.
  • This association persists regardless of metabolic syndrome status.
  • Prospective studies are needed to confirm findings and analyze causes of death.

Keywords:

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