Related Experiment Video
Updated: May 12, 2025
04:01
Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
Published on: June 14, 2024
544
Piezo1 activation protects against sepsis-induced myocardial dysfunction in a pilot study
Angwei Gong1, Jing Dai2, Yan Zhao1
1Department of Cardiology, The Second Hospital of Hebei Medical University, Hebei, 050000, China.
Scientific Reports
|May 9, 2025
Summary
Piezo1 channels protect the heart during sepsis. Activating Piezo1 improved cardiac function in sepsis-induced myocardial dysfunction, while blocking it worsened the condition, suggesting a therapeutic target.
Area of Science:
- Cardiology
- Molecular Biology
- Physiology
Background:
- Sepsis-induced myocardial dysfunction (SIMD) is a critical complication of sepsis.
- The role of mechanosensitive ion channels, like Piezo1, in SIMD remains unclear.
Purpose of the Study:
- To investigate the function of Piezo1 in SIMD.
- To elucidate the underlying molecular mechanisms involving Dual Specificity Phosphatase 3 (DUSP3).
Main Methods:
- Established a SIMD mouse model using lipopolysaccharide (LPS).
- Utilized Piezo1 agonist (Yoda1), inhibitor (GsMTx-4), and cardiomyocyte-specific Piezo1 knockout (Piezo1ΔCM) mice.
- Assessed cardiac function, histology, Piezo1, cardiac troponin T (cTnT), and DUSP3 protein levels.
Main Results:
- SIMD mice showed impaired cardiac function, elevated Piezo1, and cTnT.
- Piezo1 activation improved cardiac function and reduced injury; inhibition exacerbated SIMD.
- Piezo1ΔCM mice exhibited worsened cardiac dysfunction and injury, with elevated DUSP3.
Conclusions:
- Piezo1 plays a protective role in sepsis-induced myocardial dysfunction.
- Piezo1 may exert its protective effects by modulating DUSP3 levels.
- Targeting Piezo1 could be a potential therapeutic strategy for SIMD.
