Related Experiment Video

Updated: Jul 5, 2026

Unveiling Therapeutic Opportunities with Melanoma Patient-derived Organoid Models
05:33

Unveiling Therapeutic Opportunities with Melanoma Patient-derived Organoid Models

Published on: September 6, 2024

PRL-3: unveiling a new horizon in cancer therapy

Zi-Tong Cao1,2,3, Jia-Luo Mao2,3,4, Chang-Ying Huang2,5,6

  • 1Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China.

Acta Pharmacologica Sinica
|May 9, 2025
PubMed

Insights

Protein tyrosine phosphatase (PTP) PRL-3 drives cancer invasion and metastasis. Emerging therapies targeting PRL-3 show promise for improved cancer treatment outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • PRL-3, a protein tyrosine phosphatase (PTP), is implicated in cancer pathogenesis.
  • Overexpression of PRL-3 correlates with tumor invasion, metastasis, and poor prognosis.

Purpose of the Study:

  • To review the multifaceted roles of PRL-3 in various cancers and tumor microenvironments.
  • To discuss current and emerging therapeutic strategies targeting PRL-3.

Main Methods:

  • Literature review of studies on PRL-3 function and therapeutic interventions.
  • Analysis of PRL-3's involvement in cell proliferation, migration, and metabolic processes.
  • Examination of PRL-3's interaction with the tumor microenvironment.

Main Results:

  • PRL-3 influences tumor cell behavior, survival, and dissemination.
  • Targeted therapies including small molecule inhibitors and monoclonal antibody PRL-3-zumab show therapeutic potential.
  • Innovative strategies like CAAX motif-targeting and degradation are under development.

Conclusions:

  • PRL-3 is a significant oncogenic driver with diverse roles in cancer.
  • Targeting PRL-3 offers promising avenues for novel cancer treatments.
  • Further research into PRL-3-directed therapies could lead to more effective interventions.
Keywords:
PRL-3-zumabPhosphatase of Regenerating Liver-3 (PRL3)targeted therapiestumor metastasis

More Related Videos

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy07:33

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K