Related Experiment Video

Updated: May 11, 2026

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR
15:16

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

17.2K

Disease burden of rotavirus related diarrhea in children under 5 years in China: a meta-analysis

Li Cai1, Bicheng Tang2, Fanxu Kong1,3

  • 1Division of Infectious Disease, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

Scientific Reports
|May 9, 2025
PubMed

Insights

Rotavirus (RV) causes severe diarrhea in young children in China. This analysis of 73 studies shows a 24.7% RV positivity rate, with G9P[8] as the dominant genotype, necessitating enhanced surveillance.

Area of Science:

  • * Pediatric Infectious Diseases
  • * Public Health Surveillance
  • * Virology

Background:

  • * Rotavirus (RV) is a significant pathogen causing severe diarrhea in children under five globally and in China.
  • * Understanding the disease burden and circulating strains is crucial for effective public health interventions.

Purpose of the Study:

  • * To conduct a meta-analysis assessing the disease burden of rotavirus-related diarrhea in China from 2013-2023.
  • * To analyze rotavirus incidence, positivity rates, and predominant genotypes in children under five.
  • * To evaluate the impact of RotaTeq® licensure and the COVID-19 pandemic on rotavirus prevalence.

Main Methods:

  • * Systematic meta-analysis of 73 studies.
  • * Data sourced from PubMed, Web of Science, China National Knowledge Infrastructure, and Wanfang databases.
  • * Analysis focused on rotavirus-related diarrhea incidence and positivity rates in children under five.

Main Results:

  • * Pooled rotavirus positivity rate in children under five was 24.7%.
  • * The G9P[8] genotype was predominant, accounting for 71.7% of cases.
  • * Rotavirus positivity declined post-RotaTeq® licensure and COVID-19 pandemic, but incidence rates varied.

Conclusions:

  • * Rotavirus remains a substantial public health concern for young children in China.
  • * The predominance of the G9P[8] genotype highlights the need for targeted surveillance.
  • * Enhanced surveillance of rotavirus incidence and genotypes is imperative for disease control.

More Related Videos

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children10:57

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children

Published on: August 22, 2012

23.4K
Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

8.5K

Related Concept Videos

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...