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Intercellular junctions in the developing rat corneal endothelium.

P Montcourrier, M Hirsch

    Ophthalmic Research
    |January 1, 1985
    PubMed
    Summary
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    During rat corneal endothelium development, intercellular junctions like tight and gap junctions form. However, these junctions are not impermeable to tracers during this critical morphogenesis phase.

    Area of Science:

    • Developmental Biology
    • Cell Biology
    • Ophthalmology

    Background:

    • Corneal endothelium development is crucial for vision.
    • Understanding cell-cell interactions during morphogenesis is key.

    Purpose of the Study:

    • To investigate surface events and intercellular contacts during rat corneal endothelium morphogenesis.
    • To characterize the development and permeability of apical junctions.

    Main Methods:

    • Scanning and transmission electron microscopy.
    • Freeze-fracture technique.
    • Use of lanthanum as an ultrastructural tracer.

    Main Results:

    • Cell confluency achieved by day 16-17 of fetal development.

    Related Experiment Videos

  • Interdigitated finger-like processes and apical tight/gap junctions formed upon cell contact.
  • Tight junctions showed irregular thickness and did not form an impermeable barrier to lanthanum tracer.

    • Conclusions:

    • Apical junctions in developing corneal endothelium are initially permeable to tracers.
    • Morphogenesis involves dynamic cell surface changes and junctional development.
    • Further research needed on the functional implications of early junctional permeability.