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Related Concept Videos

Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

261
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
261
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

56
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
56

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Re-evaluating the role of TRPV6 deficiency in human and mouse pancreatitis.

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Updated: Apr 12, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Strain-specific differences in cerulein-induced acute and recurrent acute murine pancreatitis.

Alexandra Demcsák1, Thanh Tran2, Miklós Sahin-Tóth1

  • 1Department of Surgery, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Scientific Reports
|May 9, 2025
PubMed
Summary

Different mouse strains exhibit varying responses to cerulein-induced pancreatitis. FVB/N mice show more severe acute pancreatitis than C57BL/6N mice, with distinct patterns in recurrent attacks.

Keywords:
Acute pancreatitisC57BL/6NCerulein-induced pancreatitisFVB/NMouse modelsRecurrent acute pancreatitis

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Area of Science:

  • Gastroenterology
  • Pathology
  • Immunology

Background:

  • Cerulein-induced pancreatitis is a common mouse model for studying pancreatic diseases.
  • Inbred mouse strains display differential susceptibility to cerulein-induced pancreatitis.

Purpose of the Study:

  • To characterize and compare the severity of acute and recurrent acute pancreatitis in C57BL/6N and FVB/N mouse strains.
  • To elucidate the molecular mechanisms underlying strain-specific pancreatitis responses.

Main Methods:

  • Induction of acute and recurrent acute pancreatitis using cerulein hyperstimulation in C57BL/6N and FVB/N mice.
  • Assessment of pancreatitis severity through pancreatic edema, plasma amylase levels, inflammatory cell infiltration, and acinar cell necrosis.
  • Measurement of trypsin activity and analysis of SPINK1 and cathepsin L expression.

Main Results:

  • FVB/N mice exhibited more severe acute pancreatitis, characterized by greater edema, elevated amylase, increased inflammation, and necrosis compared to C57BL/6N mice.
  • FVB/N mice displayed higher and more sustained trypsin activity, linked to lower SPINK1 and cathepsin L expression.
  • In FVB/N mice, recurrent pancreatitis showed reduced edema and amylase but increased inflammation compared to the initial attack.

Conclusions:

  • Inbred mouse strains, specifically C57BL/6N and FVB/N, demonstrate distinct pathological responses to cerulein-induced acute and recurrent acute pancreatitis.
  • Differences in trypsin regulation, involving SPINK1 and cathepsin L, contribute to strain-specific pancreatitis severity.
  • Recurrent pancreatitis exhibits unique inflammatory profiles that vary between mouse strains.