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Transition Metal-Catalyzed Aminocarbonylation Reactions
Fatemeh Doraghi1, Mohammad Hossein Morshedsolouk1,2, Niki Raisi3
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Chemical Record (New York, N.Y.)
|May 9, 2025
Summary
Transition-metal-catalyzed aminocarbonylation reactions efficiently synthesize amides using carbon monoxide (CO) and amines. This review covers diverse metal catalysts for these vital organic synthesis reactions over the last ten years.
Area of Science:
- Organic Chemistry
- Catalysis
- Medicinal Chemistry
Background:
- Amides are crucial functional groups found in pharmaceuticals, natural products, and polymers.
- Aminocarbonylation reactions offer a direct route to amide synthesis.
- Carbon monoxide (CO) serves as an inexpensive and abundant C1 building block.
Purpose of the Study:
- To review recent advances in transition-metal-catalyzed aminocarbonylation reactions.
- To highlight the use of carbon monoxide (CO) and amines in amide synthesis.
- To cover catalytic systems involving palladium, rhodium, ruthenium, iridium, iron, copper, and cobalt.
Main Methods:
- Literature review of transition-metal-catalyzed aminocarbonylation reactions.
- Focus on reactions utilizing carbon monoxide (CO) and amines.
- Analysis of catalytic systems employed over the past decade.
Main Results:
- Aminocarbonylation reactions are versatile for synthesizing amides and heterocycles.
- A wide range of transition metals effectively catalyze these transformations.
- Recent developments have expanded the scope and efficiency of these reactions.
Conclusions:
- Transition-metal-catalyzed aminocarbonylation is a powerful tool for organic synthesis.
- The use of CO and amines provides access to valuable amide structures.
- Continued research promises further innovations in this field.
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