Comparison of total oxidative state, total antioxidative state, serum paraoxonase activity, and thiol levels before and after 6 months of treatment in patients with multiple sclerosis who have been recently started on new therapy agents
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View abstract on PubMed
Summary
This summary is machine-generated.Immunomodulator therapies may reduce oxidative stress in patients. Six months of treatment improved total antioxidative state (TAS) and paraoxonase (PON) activity, indicating a protective effect and potential for therapy response evaluation.
Area Of Science
- Neuroimmunology
- Biochemistry
- Oxidative Stress Research
Background
- Oxidative stress plays a role in various neurological conditions.
- Evaluating treatment efficacy is crucial for managing these diseases.
Purpose Of The Study
- To assess changes in oxidative stress markers after immunomodulator therapy.
- To determine if these markers can predict treatment response.
Main Methods
- Studied 39 patients diagnosed with neurological conditions using the revised McDonald Criteria.
- Measured total oxidative state (TOS), total antioxidative state (TAS), paraoxonase (PON) activity, oxidative stress index (OSI), and thiol/disulfide levels before and after 6 months of therapy.
Main Results
- Significant increases in native thiol/total thiol (SH/SH+SS), PON activity, and TAS were observed post-treatment (p = 0.001).
- No correlation found between disease duration, sex, or specific therapy agents and oxidative stress parameters.
Conclusions
- TAS and PON activity can serve as indicators of therapeutic response to immunomodulator treatments.
- Immunomodulator therapies demonstrate a potential protective effect by reducing oxidative stress markers.
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