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Paraoxonase 1 Enzyme Activity in Patients With Isolated Coronary Artery Ectasia
Vedat Aslan1, Sait Terzi2, Kemal Yeşilcimen2
1Department of Cardiology, School of Medicine, Istinye University, Istanbul, TUR.
Objective:
Paraoxonase 1 (PON1) is an organophosphate ester hydrolase associated with high-density lipoprotein (HDL). The recently emphasized function of PON1 activity is its antiatherogenic activity. PON1 is always found together with HDL in plasma, and PON1 is responsible for the protective effect of HDL against low-density lipoprotein (LDL) oxidation. Considering this role in cardiovascular diseases and its antioxidant properties, PON1 activity may be a valuable biomarker in predicting coronary artery ectasia (CAE), whose pathogenesis has not yet been fully elucidated. The aim was to reveal the relationship between PON1 activity and isolated CAE.
Method:
This prospective case-control study's population comprises 5240 patients who underwent coronary angiography between December 2009 and April 30, 2010. Thirty patients with isolated CAE (Group CAE) and 25 volunteers with normal coronary arteries (Group Control) who met the inclusion criteria were included in the study. The sociodemographic, clinical, and anatomical characteristics and lipid profiles of the patients were analyzed. Groups CAE and control were compared in terms of PON1 activity levels.
Results:
There was no significant difference between Group CAE (n=30) and Group Control (n=25) in terms of sociodemographic and clinical characteristics (p>0.05). There was ectasia in a single coronary artery in 19 patients (63.3%). The right coronary artery (RCA) was ectasian in 17 patients (38.6%) and was the most affected vessel. According to the Markis classification, the most common type of ectasia was type IV ectasia, which was seen in 14 patients (46.7%). When lipid profiles were compared, no difference was observed between the groups. PON1 activity levels were significantly lower in the CAE group than in the control group (Group CAE=127.5 U/L; Group Control=177.0 U/L; p<0.001).
Conclusions:
This study's findings suggest a significant correlation between low PON1 activity levels and the development of isolated CAE, suggesting that PON1 activity may play a potential role in the pathophysiology of CAE. Based on the association demonstrated between isolated CAE and PON1 activity in our study, future research may investigate the potential use of PON1 as a biomarker.
