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Updated: May 17, 2025
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Hyperpolarized Xenon for NMR and MRI Applications
Published on: September 6, 2012
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Consensus Recommendations for Hyperpolarized [1-13C]pyruvate MRI Multi-center Human Studies.
Shonit Punwani1,2, Peder Ez Larson3, Christoffer Laustsen4
1Department of Radiology, University College London Hospital NHS Foundation Trust, London, UK.
Arxiv
|May 9, 2025
Summary
Consensus on best practices for multi-center human studies using hyperpolarized (HP) [1-13C]pyruvate MRI was established. Experts agreed on key aspects of preparation, acquisition, and analysis for reproducible metabolic imaging.
Area of Science:
- Medical Imaging
- Metabolic Imaging
- Hyperpolarized Contrast Agents
Background:
- Hyperpolarized (HP) [1-13C]pyruvate MRI enables in-vivo metabolic assessment.
- Its translation into multi-center human studies necessitates standardized best practices.
Purpose of the Study:
- To establish consensus on best practices for multi-center human studies using HP [1-13C]pyruvate MRI.
- To provide recommendations for reproducible clinical applications.
Main Methods:
- A 2-round formal consensus-building exercise involving 29 experts from 13 sites.
- Experts covered pharmacy methods, MR physics, translational imaging, and data analysis.
- 246 statements were evaluated across four key areas.
Main Results:
- Consensus was reached on approximately two-thirds of statements.
- Agreement was found on release criteria for HP pyruvate preparation and the need for phantom-based site qualification and consistent field strength.
- Preference for normalized metabolite area-under-curve (AUC) values and metabolite AUC as key metrics was established.
Conclusions:
- Areas of consensus for multi-center HP [1-13C]pyruvate MRI studies were confirmed.
- Further research is needed to define best practices in areas lacking full agreement.
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