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Related Experiment Video

Updated: Jul 24, 2026

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
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Sex-based Influences on White Matter Tract Integrity in Alcohol Use Disorder: a Systematic Review.

Nathalie Barrios1, Nathania Nartey2,3, Johnny Yue2

  • 1Department of Psychiatry, School of Medicine, Yale University, 40 Temple Street, Suite 7C, New Haven, CT 06519, USA.

Current Addiction Reports
|May 9, 2025
PubMed
Summary

This review found mixed evidence on sex differences in white matter integrity in alcohol use disorder (AUD). Future research needs larger studies to clarify these neurobiological mechanisms for better AUD treatments.

Keywords:
Alcohol use disorderDiffusion magnetic resonance imagingDiffusion tensor imagingSex differencesWhite matter tract integrity

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Area of Science:

  • Neurobiology
  • Neuroimaging
  • Addiction Science

Background:

  • Women face greater alcohol-related health issues, including neurotoxicity.
  • Understanding sex differences in alcohol use disorder (AUD) neurobiology is crucial for personalized treatments.

Purpose of the Study:

  • To systematically review literature on sex differences in white matter integrity in individuals with heavy drinking or AUD.
  • To provide recommendations for future research directions.

Main Methods:

  • Systematic literature review adhering to PRISMA guidelines.
  • Searched PubMed and Google Scholar databases until January 1, 2024.
  • Included studies examining white matter integrity using diffusion magnetic resonance imaging (dMRI) in heavy drinkers/AUD.

Main Results:

  • Twelve studies met inclusion criteria from 565 initial studies.
  • Nine studies (75%) reported sex-related differences in white matter integrity.
  • Five studies indicated greater white matter degradation in women; four indicated greater degradation in men.

Conclusions:

  • The findings on sex differences in AUD-related white matter integrity are currently equivocal.
  • Larger, well-characterized studies are needed to investigate these differences.
  • Future research should control for factors like alcohol history, age, substance use, and comorbidities.