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Thromboelastography Maximum Amplitude Is a Valuable Biomarker for Early Atherosclerosis in Rheumatoid Arthritis
Qing-Lin Zhang1, Qian Xu1, Rong Huang1
1Department of Blood Transfusion, Yancheng Third People's Hospital, the Affiliated Hospital of Jiangsu Vocational College of Medicine, Affiliated Hospital 6 of Nantong University, Yancheng, Jiangsu, China.
The Kaohsiung Journal of Medical Sciences
|May 9, 2025
Summary
Thromboelastography maximum amplitude (MA) is a key indicator for early atherosclerosis in rheumatoid arthritis patients. Combining MA with fibrinogen, LDL-C, and aAIP improves early detection accuracy.
Area of Science:
- Rheumatology
- Cardiology
- Hematology
Background:
- Rheumatoid arthritis (RA) patients exhibit hypercoagulability, accelerating atherosclerosis (AS) progression.
- Thromboelastography (TEG) is a valuable tool for assessing coagulation status.
Purpose of the Study:
- To evaluate the clinical efficacy of TEG parameters in detecting hypercoagulability and subclinical AS in RA patients.
- To identify independent risk factors for early AS in RA patients.
Main Methods:
- A cross-sectional study involving 372 RA patients and 105 healthy controls.
- Assessment of TEG indices, conventional coagulation markers, and biochemical profiles.
- Multivariable logistic modeling and receiver operating characteristic (ROC) analyses were employed.
Main Results:
- RA patients demonstrated a hypercoagulable state compared to controls, more pronounced in those with early AS.
- TEG maximum amplitude (MA) emerged as an independent risk factor for early AS in RA patients (OR=1.219).
- Fibrinogen (FIB), LDL-C, and aAIP were also identified as independent risk factors. MA achieved an AUC of 0.711 for early AS diagnosis, enhanced to 0.831 when combined with FIB, LDL-C, and aAIP.
Conclusions:
- TEG maximum amplitude (MA) is a valuable biomarker for the early detection of AS in RA patients.
- Integrating MA with FIB, LDL-C, and aAIP significantly improves diagnostic accuracy for early AS in RA.
- These findings support the clinical utility of MA in risk stratification and early intervention for AS in RA.
