Safflower Yellow Pigment Alleviates Cerebral Ischemia-Reperfusion Injury via Protein Nitration and Oxidative
Kun Wang1, Xi Zhang2, Yang Zhao2
1Department of Neurology, Xingtai Central Hospital, Xingtai, Hebei Province, China.
Objective:
We seek to investigate the efficacy of safflower yellow pigment in mitigating cerebral ischemia-reperfusion injury by examining its effects on protein nitration and oxidative modification.
Methods:
A total of 160 patients with acute ischemic stroke admitted to the department of neurology of Xingtai people's hospital were included in this study. This study was a retrospective study. Patients were divided into the control group (n = 80) and the observation group (n = 80) according to whether safflower yellow pigment was used. The control group received conventional treatment, and the observation group received safflower yellow pigment.
Results:
Baseline characteristics did not significantly differ between the two groups (p > 0.05). Serum nitrosine levels were lower in the observation group compared to the control group after 24 h and one week of treatment (p < 0.05). Similarly, serum carbonylated protein levels were lower in the observation group after 24 h and one week of treatment (p < 0.05). The observation group exhibited lower NIHSS and modified rankin scale (mRS) scores, reduced cerebral ischemic area. Furthermore, levels of malondialdehyde (MDA), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α) were lower, while superoxide dismutase (SOD) activity was higher in the observation group compared to the control group after one week of treatment (p < 0.05).
Conclusion:
Safflower yellow pigment demonstrates significant neuroprotective effects in patients with cerebral ischemia-reperfusion injury by reducing protein oxidation and nitration, improving neurological function, reducing cerebral ischemic area, and attenuating oxidative stress and inflammation.
