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Biocompatibility Assessment of an Injectable Carbon Nanotube-Functionalized Reverse Thermal Gel for Cardiac Tissue

Brisa Peña1,2,3, Susanna Bosi4, Walter E Knight3

  • 1Bioengineering Department, University of Colorado Denver Anschutz Medical Campus, at Bioscience 2 1270 E. Montview Avenue, Suite 100, Aurora, Colorado 80045, United States.

ACS Applied Bio Materials
|May 9, 2025
PubMed
Summary

Researchers developed an injectable hydrogel (RTG-CNT) for heart failure treatments. This biocompatible material shows promise for cardiac tissue engineering, offering a new therapeutic delivery method.

Keywords:
carbon nanotubescardiac tissue engineeringconductive hydrogelinjectable hydrogelreverse thermal gel

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Area of Science:

  • Biomaterials Science
  • Cardiovascular Research
  • Regenerative Medicine

Background:

  • Heart failure (HF) presents a significant global health challenge, with limited treatment options beyond cardiac transplantation.
  • Current HF therapies lack the ability to regenerate or restore cardiac muscle function.
  • Effective and targeted delivery of novel cardiac therapies remains a critical unmet need.

Purpose of the Study:

  • To evaluate the biocompatibility of an injectable, thermoresponsive, conductive hydrogel (RTG-CNT) for cardiac applications.
  • To assess the potential of RTG-CNT for in vivo and in vitro cardiac tissue engineering.
  • To validate RTG-CNT as a promising platform for targeted cardiac therapy delivery.

Main Methods:

  • Development of an injectable reverse thermal gel (RTG) functionalized with carbon nanotubes (CNTs) to form RTG-CNT.
  • In vivo assessment of RTG-CNT biocompatibility via intracardial injection in a mouse model.
  • In vitro evaluation using 3D cultures of human-induced pluripotent stem cell-derived cardiomyocytes.

Main Results:

  • The RTG-CNT hydrogel demonstrated excellent biocompatibility in both in vivo and in vitro preclinical models.
  • The thermoresponsive nature of RTG-CNT allows for in situ gelation post-injection, facilitating localized delivery.
  • Results support the potential of RTG-CNT for advanced cardiac tissue engineering strategies.

Conclusions:

  • The RTG-CNT hydrogel is a biocompatible material suitable for cardiac applications.
  • This novel hydrogel holds significant potential for cardiac tissue engineering and targeted therapy delivery in heart failure.
  • Further development of RTG-CNT could lead to innovative treatments for cardiovascular diseases.