Related Experiment Video
Updated: May 12, 2025

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
A Comparative Analysis of Full and Partial Gender-Affirming Facial Surgeries Surgical Complications and Trends:
Amitai S Miller1,2, Peter Willenborg3, Clay B Beagles4
1Harvard University John F. Kennedy School of Government, Cambridge, MA, USA. Amiller@hms.harvard.edu.
Background:
Gender-affirming facial surgery (GAFS) can be performed as a full, single-staged procedure (F-GAFS) or in multiple, partial stages (P-GAFS). P-GAFS addresses either the upper, middle, or lower facial thirds, while F-GAFS includes procedures performed on multiple facial regions during a single anesthetic event. This study assesses the safety profile of GAFS, comparing surgical complications between F-GAFS and P-GAFS.
Methods:
Data from the NSQIP databases spanning 2012-2022 were analyzed. Surgical complications included return to the operating room, hospital readmission, urinary tract infection, surgical site infection, and wound dehiscence. T-tests and chi-square tests were used to assess the relationship between complications and patient and surgical characteristics.
Results:
A total of 552 patients underwent GAFS, with 193 (35.0%) undergoing P-GAFS and 359 (65.0%) undergoing F-GAFS. The prevalence of GAFS increased by 1725% over the ten-year study period. Nineteen patients (3.4%) had surgical complications. Fifteen patients had surgical site infections, three had bleeding requiring transfusion, and one had a pulmonary embolism. There were complications in 2.1% of P-GAFS patients (n = 4) and 4.2% of F-GAFS patients (n = 15). No statistically significant difference in complication rates was observed between F-GAFS and P-GAFS. Undergoing genioplasty was associated with increased complication risk (p = 0.02).
Conclusions:
Our findings underscore the increasing popularity of GAFS while also highlighting the safety of both F-GAFS and P-GAFS for transgender and gender-diverse patients. These results support informed decision-making to optimize aesthetic goals and mitigate complications. Insurers should guarantee coverage for both approaches, providing surgeons and patients the most flexibility in choosing a surgical strategy.
Level Of Evidence Iv:
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

