Global research trends in tumor-associated macrophage studies: a bibliometric analysis

Macrophages play a critical role in various diseases, including cancer, where their involvement is characterized by a dual nature. There is a growing focus on tumor-associated macrophages (TAMs) in cancer research due to their complex interactions with tumor biology. With the expanding body of research in this area, a retrospective analysis of published articles is warranted to gain insights into evolving trends. This bibliometric study aims to assist researchers in identifying key areas of interest and emerging directions within the field of TAM research.

A bibliometric analysis was performed using the Bibliometrix Package in R Software and CiteSpace software.

The volume of research on TAMs continues to increase, with this study identifying major contributors to the field. The focus of research has shifted from traditional methods, such as flow cytometry and histological techniques, toward single-cell omics approaches, which offer unbiased insights into TAM heterogeneity. Current areas of interest include biomarkers, immune therapies, TAM states, tumor microenvironments, macrophage-targeted agents, and the response of TAMs to therapeutic interventions. These topics are anticipated to remain prominent in the near future.

The study provides an overview of annual publication trends, influential papers, key journals, frequently used keywords, leading authors, and contributing institutions. It also highlights the interdisciplinary evolution of TAM-related research and the connections between these areas of study.