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Updated: Jul 10, 2026
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Fundus fluorescein angiography findings in eyes initially diagnosed with idiopathic epiretinal membrane
Chen Chen1, Qi Zhang1, Linrui Li2
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, China.
Introduction:
The aim of this study was to investigate the fundus fluorescein angiography (FFA) findings in eyes initially diagnosed with idiopathic epiretinal membrane (iERM) and assess their impact on best-corrected visual acuity (BCVA).
Methods:
This retrospective comparative study included 136 patients (151 eyes) diagnosed with iERM and a control group of 121 healthy fellow eyes. All patients underwent FFA and optical coherence tomography (OCT). The primary outcomes summarized the characteristics of FFA and OCT in patients with iERM, and analyzed the relationship between FFA findings and visual acuity.
Results:
Vascular leakage (P = 0.009) were significantly more prevalent in eyes with iERM compared to controls. Multivariate logistic regression analysis indicated that optic disc hyperfluorescence (OR 4.05; 95% CI 1.79-9.17; P = 0.001) were more likely to present in eyes with iERM. A lower OCT stage, fovea-recognizable, cellophane macular reflex type were associated with better BCVA.
Conclusion:
Optic disc hyperfluorescence is independent risk factors of iERM. Howerer, these abnormalities do not show a significant association with visual function. The precise etiology remains to be fully elucidated.
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