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Reduced dose fludarabine and cyclophosphamide lymphodepletion before tumor-infiltrating lymphocyte therapy in

Muhammad Umair Mushtaq1, Haitham Abdelhakim1, Luke Selby2

  • 1Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.

Future Oncology (London, England)
|May 9, 2025
PubMed
Abstract

Keywords:
Tumor-infiltrating lymphocytesclinical trial protocolimmunotherapylymphodepletion chemotherapymetastatic melanoma

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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