Related Experiment Video
Updated: May 12, 2025
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
The bidirectional interplay between gut dysbiosis and surgical complications: A systematic review
Lindsey Nichols1, Omar El-Kholy2, Ahmed Adham R Elsayed3
1College of Medicine, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Background:
The gut microbiome critically influences diverse aspects of physiology and surgical recovery. Conversely, surgery alters the microbiome, potentially predisposing to complications. We aimed to clarify the bidirectional interaction between surgery and gut dysbiosis.
Methods:
On December 22nd, 2024, a systematic search of the Cochrane Library, PubMed, VHL, and WOS was completed. Relevant studies were assessed for risk of bias using STROBE and CONSORT guidelines.
Results:
Thirty studies, with 2500+ participants experiencing diverse procedures and complications, were incorporated. Although specifics varied, dysbiosis correlated with surgery and its complications. Patients with complications had more harmful bacteria and fewer beneficial bacteria. In some studies, probiotics reduced complications.
Conclusion:
Gut dysbiosis is tied to postoperative complications in a complex, bidirectional relationship. Patients with surgical complications may have fewer beneficial and more pathogenic bacteria both before and after surgery. Early identification of dysbiosis and probiotic administration could predict or even reduce postoperative complications.
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