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Related Concept Videos

Voltammetric Techniques: Cyclic Voltammetry01:10

Voltammetric Techniques: Cyclic Voltammetry

307
Cyclic voltammetry (CV) is an electrochemical technique used to investigate the redox properties of a chemical species. It involves measuring the current response of an electrochemical cell as a function of the applied potential. The setup for cyclic voltammetry typically consists of a working electrode, a reference electrode, and a counter electrode—all immersed in an electrolyte solution. The working electrode is where the redox reaction of interest occurs, while the reference electrode...
307
Voltammetry: Stripping Methods01:13

Voltammetry: Stripping Methods

135
Anodic Stripping Voltammetry (ASV), Cathodic Stripping Voltammetry (CSV), and Adsorptive Stripping Voltammetry (AdSV) are electrochemical techniques used to determine trace amounts of analytes in solution. These methods involve applying a potential to an electrode and measuring the resulting current.
Anodic Stripping Voltammetry (ASV)
ASV is used to determine metals and metalloids at trace levels. It involves two steps: deposition and stripping. First, a negative potential is applied to the...
135
Voltammetric Techniques: Linear-Scan (E vs Time)01:12

Voltammetric Techniques: Linear-Scan (E vs Time)

180
Polarography is a classical voltammetric technique used to analyze electrochemical reactions. This method applies a linear potential sweep to a dropping mercury electrode (DME), and the resulting current is measured. A dropping mercury electrode is commonly used as the working electrode in polarography. It consists of a capillary tube filled with mercury, where the tiny droplet forms at the tip. This droplet continuously drops from the capillary, creating a new electrode surface for each...
180
Voltammetric Techniques: Pulse Voltammetry01:17

Voltammetric Techniques: Pulse Voltammetry

252
Differential-pulse voltammetry (DPV) is a type of voltammetry that involves applying a series of voltage pulses to an electrochemical cell while measuring the resulting current. In DPV, the differential pulse or small potential pulses are superimposed on a linear potential sweep. The magnitude of these pulses is typically small, often in the millivolt range. Each voltage pulse lasts a short duration, usually in the order of a few milliseconds, and is applied at regular intervals along the...
252
Voltammetry: Overview01:20

Voltammetry: Overview

202
Voltammetry is an electroanalytical technique in which the current flowing through an electrochemical cell is measured as a function of applied potential, typically under conditions of concentration polarization. The technique provides valuable information about redox-active species, and the current response is plotted as a voltammogram.
A voltammetric cell uses three electrodes: a working electrode, a reference electrode, and an auxiliary electrode. The redox reactions occur in the working...
202
Voltammetry: Factors Affecting Measurements01:21

Voltammetry: Factors Affecting Measurements

111
A current produced due to the redox reactions of the analyte at the working and auxiliary electrodes is called a faradaic current. The reaction can be divided into two types. The current generated due to the reduction of the analyte is called cathodic current, and it carries a positive charge. In contrast, the current produced by analyte oxidation is known as an anodic current, and it has a negative charge. The applied potential at the working electrode determines the faradaic current flow, and...
111

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Updated: May 12, 2025

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry
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Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry

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Tracking Carbon Microelectrode Impedance during Fast-Scan Cyclic Voltammetry.

Carl J Meunier1, Gregory S McCarty1,2, Leslie A Sombers1,2

  • 1Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, United States.

ACS Sensors
|May 9, 2025
PubMed
Summary
This summary is machine-generated.

Fast-scan cyclic voltammetry (FSCV) performance shifts in vivo can now be monitored. Incorporating electrochemical impedance spectroscopy (EIS) provides real-time data for improved neurochemical analysis accuracy.

Keywords:
capacitancedopamineelectrochemical conditioningelectrochemical impedance spectroscopyelectrode driftfoulingfrequencymicroelectrode

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Area of Science:

  • Neuroscience
  • Analytical Chemistry
  • Biomedical Engineering

Background:

  • Fast-scan cyclic voltammetry (FSCV) monitors neurochemical dynamics in vivo using carbon-fiber microelectrodes.
  • Electrode performance variability and biological responses impact FSCV data accuracy.
  • Previous work used RC circuits to model in vivo FSCV performance shifts.

Purpose of the Study:

  • To integrate electrochemical impedance spectroscopy (EIS) into FSCV sweeps.
  • To quantify rapid changes in electrochemical system parameters during FSCV experiments.
  • To develop a method for real-time monitoring and potential in situ calibration of FSCV.

Main Methods:

  • Incorporated EIS measurements within each FSCV sweep.
  • Collected data using standard FSCV equipment.
  • Quantified shifts in impedance, reactance, and capacitance in vivo.

Main Results:

  • EIS successfully captured significant parameter shifts upon tissue implantation.
  • Electrochemical conditioning largely mitigated these observed shifts.
  • The paired FSCV:EIS approach provides real-time performance insights.

Conclusions:

  • The integrated FSCV:EIS method offers a significant advancement for in vivo neurochemical monitoring.
  • This technique can inform users about electrochemical performance changes during experiments.
  • It represents a step towards in situ calibration and enhanced data analysis accuracy.