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Development of a new ambulatory oxygen delivery method combining continuous oxygen flow and demand oxygen delivery

Kazuya Shingai¹, Tomoyuki Ikeuchi², Peter Rassam³

¹Pulmonary Rehabilitation Center, Kirigaoka Tsuda Hospital, 3-9-20, Kirigaoka, Kokurakita, Kitakyusyu, Fukuoka, 802-0052, Japan; Clinical Research Institute, Kirigaoka Tsuda Hospital, 3-9-20, Kirigaoka, Kokurakita, Kitakyusyu, Fukuoka, 802-0052, Japan; Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki, 852-8520, Japan.

Respiratory Medicine

|May 9, 2025

Abstract

Background And Objective:

Although demand oxygen delivery system (DODS) prolongs ambulatory oxygen supply, the efficacy of preventing hypoxemia is likely to be lower than continuous oxygen flow (CF). We developed a new oxygen delivery method combining CF and DODS (CF + DODS). This study aimed in comparing the efficacy between conventional oxygen delivery methods and a new method during walking in patients with COPD.

Methods:

We conducted three-treatment crossover study. Stable COPD patients performed three 6-min walk tests (6MWT) with different oxygen delivery methods in random order with CF, DODS, and CF + DODS.

Results:

Twenty-six COPD patients were included in the study. The linear mixed model on SpO₂ revealed significant main effects of oxygen conditions (P < 0.001) and exercise time (P < 0.001), however no significant interaction (P = 0.537). In the post-hoc analysis, SpO₂ in DODS was significantly lower than in CF and CF + DODS throughout the 6MWT. CF and CF + DODS showed no significant differences in SpO₂ at any exercise timepoint. There were no significant differences among each oxygen delivery method in walking distance and dyspnea before and after 6MWT. DODS utilized significantly less oxygen than CF and CF + DODS, and CF + DODS consumed significantly less oxygen than CF during 6MWT.

Conclusion:

CF + DODS enables a longer duration of oxygen supply, while preventing hypoxemia to the same degree as CF. These findings suggest that CF + DODS promotes outdoor activities in daily living while preventing hypoxemia in patients with COPD.

Trial Registration:

This study was registered in the UMIN Clinical Trials Registry (UMIN00005299).

Keywords:

Exercise test Hypoxemia Oxygen Oxygen inhalation therapy Oxygen saturation

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