Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-Reported Symptoms Versus Clinician-Measured Signs to Distinguish Sjogren's in Patients With Dry Eye.

Translational vision science & technology·2026
Same author

Recurrent retroprosthetic membranes in Boston Keratoprosthesis Type I: Incidence, risk factors, and complications.

The ocular surface·2025
Same author

Outcomes Evaluated in Randomized Controlled Trials of Treatments for Dry Eye: A Systematic Review.

Cornea·2025
Same author

Risk Factors for Development of Uveitis and Cystoid Macular Edema After Cataract Surgery.

Ocular immunology and inflammation·2025
Same author

Association of Dry Eye and Corneal Ulcers With Collagen Vascular Diseases in a Medicare Population.

Cornea·2025
Same author

Dry Eye Diagnosis is an Independent Risk Factor for Developing Depression and Anxiety Among the Elderly.

Cornea·2025

Related Experiment Video

Updated: May 12, 2025

Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration
07:39

Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration

Published on: August 4, 2023

1.8K

Feature developments in artificial corneal devices: a review.

Gavin Li1,2, Michael X Lin1,3, Maria S Cortina4

  • 1The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

The British Journal of Ophthalmology
|May 9, 2025
PubMed
Summary
This summary is machine-generated.

Artificial corneal devices offer a promising solution to the global shortage of donor corneas for transplantation. These synthetic keratoprostheses may overcome limitations of traditional corneal grafts, especially for high-risk patients and in underserved regions.

Keywords:
Clinical TrialCornea

More Related Videos

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
06:46

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

Published on: February 15, 2019

11.6K
Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

12.4K

Related Experiment Videos

Last Updated: May 12, 2025

Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration
07:39

Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration

Published on: August 4, 2023

1.8K
Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
06:46

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

Published on: February 15, 2019

11.6K
Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

12.4K

Area of Science:

  • Ophthalmology and Biomedical Engineering

Background:

  • Corneal disease is a major cause of global blindness, with donor corneal transplantation (keratoplasty) being the primary treatment.
  • Traditional penetrating keratoplasty (PK) faces challenges including graft failure, repeat surgeries, and a significant shortage of donor corneas, particularly in developing nations.
  • Emerging techniques like partial-thickness transplantation and corneal cross-linking offer less invasive alternatives for specific conditions.

Purpose of the Study:

  • To introduce fully synthetic keratoprostheses as a potential alternative to donor corneal transplantation.
  • To address the limitations of conventional keratoplasty, including allograft rejection, endothelial failure, and donor tissue scarcity.
  • To explore the feasibility of keratoprostheses in resource-limited settings by eliminating the need for eye banking.

Main Methods:

  • Design and development of novel fully synthetic keratoprostheses.
  • Surgical techniques for implantation of these artificial corneal devices.
  • Clinical trials evaluating the early outcomes and indications for use.

Main Results:

  • Keratoprostheses demonstrate promising outcomes, particularly in high-risk corneal disease cases.
  • Synthetic devices eliminate the risks associated with allograft rejection and endothelial cell failure.
  • Early clinical trial data suggests potential for widespread application, including in resource-limited areas.

Conclusions:

  • Fully synthetic keratoprostheses represent a significant advancement in treating corneal blindness.
  • These devices offer a viable solution to the global donor cornea shortage and its associated logistical challenges.
  • Further clinical evaluation is ongoing to establish the long-term efficacy and safety of synthetic keratoprostheses.