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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Related Experiment Video

Updated: Jun 13, 2025

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
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Post-Y90 PET Dosimetry.

Ali Afrasiabi1, Johannes L du Pisanie1, Bahareh Gholami1

  • 1Department of Radiology, University of North Carolina at Chapel Hill, 101 Manning Drive, Chapel Hill, NC 27514, USA.

PET Clinics
|May 9, 2025
PubMed
Summary
This summary is machine-generated.

Transarterial radioembolization (Y-90) for liver cancer shows promise with PET imaging. PET/CT and PET/MR offer superior clarity for dose assessment and treatment response, improving personalized dosimetry.

Keywords:
Interventional radiologyPETPost-treatment dosimetryRadioembolizationSingle-photon emission computed tomographyYttrium-90

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Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
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Area of Science:

  • Nuclear medicine
  • Oncology
  • Radiology

Background:

  • Transarterial radioembolization with yttrium-90 (Y-90 TARE) is a standard treatment for unresectable liver cancer.
  • Current post-treatment imaging often uses SPECT/CT, which has limitations in image quality.

Purpose of the Study:

  • To evaluate the effectiveness of advanced imaging techniques for Y-90 TARE.
  • To highlight the benefits of PET-based imaging for personalized dosimetry and treatment response assessment.

Main Methods:

  • Comparison of imaging modalities including SPECT/CT, PET/CT, and PET/MR for Y-90 TARE.
  • Assessment of image quality, dose quantification accuracy, and correlation with treatment outcomes.

Main Results:

  • PET/CT and PET/MR imaging provide higher signal-to-noise ratio and spatial resolution compared to SPECT.
  • Improved image clarity facilitates accurate radiation dose quantification and correlation with treatment response.

Conclusions:

  • PET-based imaging offers superior image quality for Y-90 TARE, enabling more precise personalized dosimetry.
  • Wider adoption of PET imaging is recommended to refine dose-response and dose-toxicity relationships, despite current availability challenges.