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Complementary therapeutic use of exercise in malaria's neurocognitive sequelae

Luciana Pereira de-Sousa1, Pamela Rosa-Gonçalves1, Beatriz Nogueira Siqueira-E-Silva1

  • 1Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.

Trends in Parasitology
|May 9, 2025
PubMed
Abstract

Keywords:
cognitive-behavioral activityexerciseinfectious-parasitic diseaseslifestyle medicinemalariaphysical activity

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Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
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