Predictive coding in the human olfactory system

The human olfactory system is unusual. It deviates from the classical structure and function of other sensory cortices, and many of its basic computations remain mysterious. These idiosyncrasies have challenged the development of a clear and comprehensive theoretical framework in olfactory neuroscience. To address this challenge, we develop a theory of olfactory predictive coding that aims to unify diverse olfactory phenomena. Under this scheme, the olfactory system is not merely passively processing sensory information. Instead, it is actively issuing predictions about sensory inputs before they even arrive. We map this conceptual framework onto the micro- and macroscale neurobiology of the human olfactory system and review a variety of neurobiological, computational, and behavioral evidence in support of this scheme.