Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Dissolution processes and surface alteration. 4. Determination of the "effective" surface].

R Neubert, W Fürst, H Frenzel

    Die Pharmazie
    |May 1, 1985
    PubMed
    Summary

    This study introduces a method to measure a drug's effective surface area using dissolution parameters. These drug surface measurements are smaller than those determined by the BET technique.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Guideline "Implantable hearing aids"-short version : German S2k guideline of the Working Group of German-Speaking Audiologists, Neurootologists and Otologists (ADANO), of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO) in collaboration with the German Society of Audiology (DGA), the German Society of Phoniatrics and Pediatric Audiology (DGPP), and patient representatives.

    HNO·2018
    Same author

    Improved directional hearing of children with congenital unilateral conductive hearing loss implanted with an active bone-conduction implant or an active middle ear implant.

    Hearing research·2018
    Same author

    [Guideline "Implantable hearing aids"-short version : German S2k guideline of the Working Group of German-speaking Audiologists, Neurootologists and Otologists (ADANO), of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO) in collaboration with the German Society of Audiology (DGA), the German Society of Phoniatrics and Pediatric Audiology (DGPP), and patient representatives].

    HNO·2018
    Same author

    [Psychometric evaluation in severe ear deformities: critical analysis of the current situation].

    HNO·2014
    Same author

    [Development of a computed tomography data-based Vibrant Bonebridge viewer].

    HNO·2014
    Same author

    Assessment of skills using a virtual reality temporal bone surgery simulator.

    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2013

    Area of Science:

    • Pharmaceutical Sciences
    • Physical Chemistry

    Context:

    • Accurate determination of drug surface area is crucial for predicting drug dissolution and bioavailability.
    • Existing methods like the Brunauer, Emmett, and Teller (BET) technique measure specific surface area, which may not directly correlate with dissolution performance.

    Purpose:

    • To develop and validate a method for measuring the
    • effective
    • drug surface area using dissolution parameters.
    • To compare the
    • effective
    • surface area obtained through dissolution models with the specific surface area measured by BET-technique.

    Summary:

    • A novel method quantifies drug effective surface area via dissolution parameters, utilizing either the Paddle-model or a resorption-model.

    Related Experiment Videos

  • The effective surface areas derived from dissolution parameters were consistently found to be smaller than those determined by the BET technique.
  • This suggests that dissolution-based surface area measurements provide a more functionally relevant assessment of drug performance.

    • Impact:

    • Provides a more physiologically relevant measure of drug surface area for formulation development and quality control.
    • Offers a complementary approach to traditional BET surface area analysis, enhancing the understanding of drug-solubility relationships.
    • Potential to improve the prediction of drug dissolution rates and in vivo performance.