Determination of some cardiac drugs using an ionselective chloride electrode and a silver electrode

To determine hydrochlorides of butobendin, carbocromen, hexobendin, lidocaine, procainamide, todrazoline in pharmaceutical preparations, two analytical techniques were applied: the direct potentiometric method (from a standard curve) using an ion-selective chloride electrode and the method of potentiometric titration using a silver electrode as well as an ion-selective chloride electrode (indirect method). A statistical analysis has been carried out, and statistical tests were applied to compare the methods used.